Cannabinoid Report: A Guide to CBDV Extraction, Storage, Price, Benefits & More

Cannabinoid Report: A Guide to CBDV Extraction, Storage, Price, Benefits & More

In this post:

  • What is CBDV?
  • Varin Cannabinoids
  • Benefits of CBDV
  • How CBDV works in the body
  • CBDV products and market
  • Potency and testing of CBDV

ACS Contact Banner - Click to Send an Email

As cannabis research deepens, it’s clear that the plant’s compounds hold great healing potential. Although CBD and THC enjoy the majority of the spotlight, there are over 100 cannabinoids in hemp and cannabis plants. Cannabidivarin (CBDV), of the “varin” subfamily, is one notable example. CBDV was discovered nearly 50 years ago. But due to federal prohibition, scientists struggled to gain access to the compound for clinical research.

Fortunately, since the 2018 Farm Bill passed, there has been a flurry of studies published on the therapeutic potential of CBDV. Some of these studies were even backed by pharmaceutical giants and the US government!

Until recently, most research was preclinical, meaning that studies focused on animals like mice, rather than humans. However, over the past few years, clinical studies on traditionally hard-to-treat disorders garnered impressive results. We've only scratched the surface of CBDV’s medical potential, but it is evident that the compound holds significant promise.

What is CBDV?

Cannabidivarin, or CBDV, is a cannabis-based chemical compound that shares almost the same molecular structure as CBD. Found in both broad-spectrum and full-spectrum extracts, it is one of over 100 cannabinoids identified from the cannabis plant that has a controlling influence on the physiological activity of cannabis in animals and humans. Specifically, it's part of the varin family.

What are “Varin” Cannabinoids?

Varin molecules, technically referred to as “varinolic cannabinoids,” include CBCV, CBDV, CBGV, and THCV. These are a family of cannabinoid compounds that have three carbon atoms in their alkyl side chain, while neutral versions of cannabinoids, like THC, feature five carbon atoms.

This difference in structure changes their binding affinity. Binding affinity determines the potency and other characteristics of these molecules when they “dock” with cellular receptors within the endocannabinoid system, essentially changing the way they interact and affect the body.

What are the Reported Benefits of CBDV?


The body’s endocannabinoid system (ECS) is directly involved with our nausea response. When certain ECS receptors are blocked, we feel nauseous. When their stimulated, nausea symptoms improve. Initial research on rodents shows that CBDV likely acts as an agonist (stimulator) to the CB1 receptors, which inhibits the nausea response.


Much of the research around CBDV has centered around its effect on seizures. GW Pharmaceuticals, which developed the first FDA-approved CBD drug, Epidiolex, is actively developing a CBDV-based drug known as GPW42006 to reduce or prevent various forms of seizures. GW’s research has shown that CBDV affects the neurochemical pathway of capsaicin receptors, which are involved in both the onset and the progression of several types of epilepsy.

Autism Spectrum Disorder (ASD)

There’s evidence that CBDV can help alleviate many common conditions associated with ASD, such as chronic anxiety, seizures, addictive behavior, and mood disorders. One study found that CBDV reduced acute anxiety in patients diagnosed with ASD by shifting the balance of the stimulating neurotransmitter, glutamate, and the relaxing neurotransmitter, GABA.

This study compared the effects of CBDV in neuro-diverse patients (those with ASD) and neurotypical patients (those without ASD) and noted a higher degree of difference in ASD patients than those without. The results showed that there is, in fact, a link between CBDV and the reduction of ASD symptoms.

Muscular Dystrophy

A study published by the National Research Council in Italy examined the effects of CBD, CBDV, and THCV on three underlying causes of Duchenne’s Muscular Dystrophy (DMD). The team found that CBD and CBDV could restore the function of impaired muscle stem cells, inflammation in the muscle tissue, and reduce defective autophagy (the orderly degradation and recycling of cells). These findings suggest that CBD and CBDV could effectively treat the underlying causes of many different forms of muscular dystrophy, not just DMD.

ACS Contact Banner - Click to Send an Email

How Does CBDV Work in the Body?

CBDV & the ECS

CBDV interacts with the endocannabinoid system (ECS), an internal biological system that regulates many functions in the body, the same way as CBD. CBDV does not directly stimulate or suppress the ECS; Instead, it modulates its receptors. Meaning it controls influence on the sensitivity of endocannabinoid receptors based on the body's internal condition.

CBDV & TRP Ion Channels

Both CBD and CBDV mediate specific TRP channels. The TRP ion channels act like sensors located throughout the body. They trigger an alert in the nervous system to detect toxic chemicals or dangerously hot or cold temperatures.

For example, excessive stimulation of the channel known as TRPA1 plays a role in migraine headaches, particularly migraines triggered by cigarette smoke, certain fragrances or aromas, high heat, or freezing temperatures.

Can CBDV Get You High?

CBDV is a non-psychotropic cannabinoid, meaning that it does not have the intoxicating effects of compounds like THC, for example.

CBDV Products

What Type of CBDV Products are Available?

Very few companies produce and sell CBDV-infused products. As more CBDV research surfaces, manufacturers will surely recognize the value of products focused on this minor cannabinoid.

Currently, CBDV tinctures, oils, and edibles are the most common products on the market. Additionally, most full-spectrum CBD, or THCV oils will also contain small amounts of CBDV.

Are There High CBDV Strains?

CBDV is found naturally in most forms of cannabis, but only in trace amounts.

Most prevalently, CBDV is seen in “landrace” strains. Landraces are strains native to certain regions of the world. In particular, Asian and African landrace cannabis strains contain high concentrations of both CBDV and THCV and lower concentrations of THC.

Cannabis cultivators have started using these plants to breed new high-potency CBDV and THCV strains. Some of the highest CBDV strains available today include:

  • Medical Mass
  • Euphoria
  • Painkiller XL
  • Royal Medic
  • Dance World
  • CBD-Victory
  • Forbidden V
  • Pine Walker

Can You Smoke, Vape, and Ingest CBDV?

Like CBD and THC, you can add CBDV to oils, tinctures, and edibles for consumption. You can also add CBDV to vape cartridges via oils and extracts or smoke flower strains that contain higher levels of CBDV.

How is CBDV Extracted?

Similar to CBD, there are multiple methods for the extraction of CBDV.

  • Solvent extraction involves using ethanol, butane, propane, isopropyl, or alcohol to extract cannabinoids.
  • CO2 extraction uses a “closed-loop extractor.” This machine contains three chambers. The first one holds pressurized, solid CO2 or dry ice; the second chamber has dried help plant material; the final chamber separates the resulting product.
  • Natural oil extraction uses a process that begins with the raw plant materials being decarboxylated (heated) to the desired temperature for a specific amount of time so that the chemicals in the plant are activated and infused into the oil.
ACS Contact Banner - Click to Send an Email

The CBDV Market

Is CBDV Legal?

CBDV derived from hemp containing no more than 0.3 percent THC is considered legal on a federal level per the 2018 Farm Bill. Although hemp-derived CBDV is difficult to find, it’s legal in all states as long as it abides by the state THC regulations.

CBDV Potency & Testing

How is CBDV Potency Measured?

Potency tests
measure CBDV the same way as CBD, THC, and other cannabinoids. ACS Laboratory uses Ultra-High-Performance Liquid Chromatography (HPLC) machinery to measure and detect CBDV levels in edibles and extracts. The HPLC instrument can test samples at room temperature without heat, which changes the results.

Why Should We Test for CBDV?

The current research is clear that CBDV offers significant anticonvulsant properties. The same research also points to the potential to use CBDV for hard-to-treat disorders like ASD and DMD. As consumers learn more about CBDV, the medicinal value of this rare yet potent cannabinoid will surely become clear.

ACS Contact Banner - Click to Send an Email

The Cannabinoids Guide

This complete cannabinoid guide covers major and minor cannabinoids, how they work in the body, and highlights the top compounds brands and operators must test for today.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

The Cannabinoid Guide

The definitive resource on leading major and minor cannabinoids, how they work in the body, and what to test for.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Related Blogs

March 20, 2023

Terpene Tuesdays: Everything You Need to Know About Sabinene Hydrate Flavor, Fragrance, and Benefits

Sabinene Hydrate is a vital component of various plant essential oils, including cannabis. It displays antioxidant, anti-inflammatory and antimicrobial uses.

Elena Schmidt

March 23, 2023

Flavonoid Friday: Everything You Need to Know About Vitexin Flavor, Fragrance, and Benefits

Vitexin fans praise it for everything from benefiting the brain and heart to fighting diabetes and helping maintain healthy blood sugar levels.

Elena Schmidt

March 15, 2023

Understanding Amanita Pantherina Mushrooms: Appearance, Effects, and Legality

The Amanita pantherina, or the Panther Cap, is a relative of the Amanita muscaria mushroom. Its cap features ochre brown dots with white spots. It's a delirium rather than a psychedelic, and it's legal!

Masha Ty

December 16, 2022

Amanita Muscaria (Fly Agaric): History & Toxicology of the Most Misunderstood Mushroom

Amanita mushrooms are fully legal in the United States and have a long history of use. Discovery Amanita mythology and toxicology in this ACS blog.

Masha Ty

January 19, 2023

Amanita Muscaria Part II: Active Ingredients, Effects, Nutrition & Legality

Exploring amanita muscaria’s psychoactive effects, toxic potential, edible preparation, and legality in the US and Canada.

Masha Ty

March 7, 2023

Terpene Tuesdays: Everything You Need to Know About Valencene Flavor, Fragrance, and Benefits

Valencene is a rare terpene found in cannabis. It exudes an herbaceous, sweet citrus aroma with woodsy notes and is abundant in citrus fruits.

Elena Schmidt

January 25, 2023

Comparing Exotic Cannabinoids: Delta-9 THC vs. Delta-8, Delta-10, HHC, HHCP, THC-O (THCOa), & THCP

The main difference between exotic cannabinoids and Delta-9 THC is their molecular structures, psychoactive intensity, and legality.

Elena Schmidt

February 24, 2023

Flavonoid Friday: Everything You Need to Know About Orientin Flavor, Fragrance, and Benefits

Orientin is a flavonoid prevalent in cannabis, bamboo leaves, and various teas is. Its impact as an antioxidant extends into numerous human therapeutic benefits.

Elena Schmidt

February 20, 2023

Terpene Tuesdays: Everything You Need to Know About Ocimene Flavor, Fragrance, and Benefits

As a cannabis terpene, ocimene offers strains potential therapeutic benefits, including anti-viral, anti-seizure, and anti-inflammation.

Elena Schmidt

Elena Schmidt

June 13, 2019

Hemp/CBD in Florida

ACS Admin

February 17, 2023

DEA Says Delta-8 and Delta-9 THCOA (aka THCO) Falls Under Controlled Substances Act, not Farm Bill

According to the DEA's interpretation of the law, THCOA doesn’t fall within the Farm Bill's definition of hemp because hemp plants don’t naturally produce the cannabinoid.

Elena Schmidt

December 8, 2022

Companies Producing Edibles Containing CBD and Delta-8 THC Receive New Warning Letters from the FDA

FDA recently issued new warning letters to companies that produce CBD and Delta-8 THC edibles.

December 9, 2022

INTERVIEW: Live Rosin Delta-8: How It's Made, Effects, Safety & Quality

Live rosin delta 8 is a cannabis concentrate made from frozen plant material and manufactured delta-8 extract. Learn more.

December 14, 2022

Visit the New and Improved ACS Laboratory Website

Enhanced education, intuitive navigation, mushroom program launch, compliance updates, and more!

Elena Schmidt

December 20, 2022

Terpene Tuesdays: Everything You Need to Know About Camphene Flavor, Fragrance, and Benefits

Research suggests that camphene possesses anti-microbial and antiviral properties, provides coughing relief, and may even be able to prevent heart disease.

Elena Schmidt

Elena Schmidt

January 30, 2023

ACS Laboratory Receives 82 Emerald Badges for Exemplary Hemp and Cannabis Test Results, More Than Any Laboratory in the USA

Recently Awarded 21 Emerald Test Proficiency Badges for 2022, ACS has Reaffirmed its Position as the Most Trusted Third-party Hemp and Cannabis Testing Provider

ACS Laboratory

January 5, 2023

Functional Mushrooms: Exploring Lion’s Mane, Cordyceps, and Reishi Benefits & Uses

Reviewing functional mushroom benefits, research, and top products, with a focus on reishi, lion’s mane, and cordyceps.

Masha Ty