Flavonoid Friday: Everything You Need to Know About Kaempferol Flavor, Fragrance, and Benefits

Flavonoid Friday: Everything You Need to Know About Kaempferol Flavor, Fragrance, and Benefits

In this post:

  • What is kaempferol
  • Health benefits of kaempferol
  • Foods high in kaempferol
  • Best form of kaempferol
  • How to get kaempferol from cannabis

Kale, spinach, broccoli — there’s a reason your mother made you eat these good-for-you greens. Nature packed these veggies and other plants, including cannabis, with potent antioxidants called flavonoids, which fight free radicals and inflammation. One unique flavonoid that gives leafy kale and green tea superfood status is kaempferol, pronounced “camp-fur-all.”

Here’s everything you need to know about disease-combating kaempferol and what it brings to your favorite cannabis strains.

What is Kaempferol?

Kaempferol is a natural substance found in many vegetables, fruits, and herbs, including broccoli, kale, tea, and Ginkgo biloba leaves. You know these foods are “healthy,” but have you ever thought about the importance of the flavonoids they contain?

Flavonoids such as kaempferol are more potent antioxidants than vitamins C and E. Studies show kaempferol’s antioxidant and anti-inflammatory properties can help reduce the risk of many chronic diseases, including cancer.

Antioxidant Properties of Kaempferol

Super antioxidants, like kaempferol, fight free radicals in the body. Free radicals are uncharged molecules with an uneven number of electrons that wreak unmitigated bodily havoc.

You can think of them as unhinged horror movie serial killers, reaping widespread destruction with no apparent motive. When free radicals react with other molecules in your body, they cause a nasty chain reaction called oxidation. Oxidative stress leads to everything from early signs of aging to cancer and heart disease.

That’s why antioxidants, or compounds that work against oxidation, are so vital to our health. Enter kaempferol! The scientific interest in kaempferol centers around its antioxidant ability and how it reduces free radical formation.

Kaempferol and Cancer

A review of kaempferol found that it can control and modify critical processes, including apoptosis (cell death), inflammation, and metastasis (cancer spread) — big words that spell bad news for our bodies. But, significantly, kaempferol helps stop the growth of cancer cells while also preserving normal cells. Some studies show it even has a protective effect in some cases.

That’s why studies link a decrease in various human cancers with consuming vegetables and fruits high in kaempferol. In other words, research implies that the more kaempferol you eat, the lower your risk of developing cancer.

  • Colon cancer: A 2014 study proved benefits from kaempferol in human colon cancer cells.
  • Breast cancer: Breast cancer spreads with the assistance of compounds called Matrix metalloproteinases, or MMPs for short. Kaempferol slows down metastasis, or the cancer cell’s invasion into other cells, by blocking MMPs.
  • Prostate cancer: In Biomedical Reports 2015, a study showed that kaempferol could block prostate cell growth to some degree.
  • Alzheimer’s disease: Researchers at Rush University Medical Center demonstrated a link between dietary measures and staying cognitively intact. Kale, beans, tea, spinach, and broccoli, the highest sources of kaempferol, resulted in a 51 percent drop in the risk of developing Alzheimer’s!

Kaempferol and Inflammation

In addition to fending off cancer, kaempferol is also well-known for its anti-inflammatory effects. Doctors associate inflammation with a range of severe health issues, including obesity, cardiovascular disease, diabetes, and hypertension.

  • A 2019 report says kaempferol demonstrated beneficial effects on chronic inflammatory diseases, including intervertebral disc (IVD) degeneration, post-menopausal bone loss and colitis, and acute inflammatory diseases, including acute lung injury (ALI).
  • In this 2020 study, kaempferol’s ability to battle oxidative stress and interact with central inflammatory processes makes it a pivotal contender to treat symptoms of disorders associated with chronic immune activation.

What Foods are High in Kaempferol?

If you’re looking to add kaempferol to your diet, you need to eat your veggies. The top 25 most kaempferol-dense foods are all vegetables. Kaempferol is abundant in:

  • Kale, spinach, and endive
  • Broccoli
  • Red and pinto beans
  • Onions and leeks
  • Green beans
  • Ginger
  • Dill, chives, and tarragon
  • Tea
  • Aloe and gingko biloba
  • Cherries and blueberries

What is the Best Form of Kaempferol?

  • The richest plant sources of kaempferol are green leafy vegetables, including spinach, kale, and herbs such as dill, chives, and tarragon.
  • The leaves of wild leeks or ramps contain 32.5 mg of kaempferol (per 100 grams fresh weight), and endives contain 24.6 mg.
  • A report on the bioavailability of kaempferol indicates that kaempferol in tea has the highest absorption rate, followed by endives and broccoli.

How the Body Processes Kaempferol

Most of the kaempferol in plants is attached to sugar moieties, and the differences in these sugars affect how well our bodies absorb the flavonoids in the plant. Our bodies absorb flavonoids like kaempferol through the gastrointestinal tract, which delivers them to the surrounding blood to reach target tissues.

A kaempferol study where participants ate endive soup showed the body mainly absorbs this flavonoid from the distal section of the small intestine. Furthermore, most participants displayed remarkably consistent pharmacokinetic profiles, meaning humans can absorb kaempferol reasonably efficiently.

How to Consume Cannabis to Get the Most Kaempferol Absorbed Into Your Body

Kaempferol has a lot of health benefits to offer, and you’re probably wondering what method of consuming cannabis allows you to reap them most effectively. The general rule of thumb says that eating cannabis is the best way to get the most flavonoids because while smoking flower can activate some flavonoids, it can also burn them up. Depending on the preparation, tinctures can serve as another route to maximize your flavonoid intake.

How Often Should I Take Kaempferol?

Kaempferol is non-toxic, and it’s already present in healthy foods at high levels, so it’s safe to say that getting more of this essential substance into your system is not a bad idea. While there is no established optimal dosage for kaempferol and other such flavonoids, you can generally find supplements with daily dosage recommendations ranging from 100 mg to 1,000 mg.

The Bottom Line

Kaempferol is a significant flavonoid found in many plants, including vegetables, fruits, and cannabis. It offers powerful antioxidant properties that battle free radicals, reducing inflammation, preventing early signs of aging, and stopping cancer cell growth.

Drinking tea and eating a diet rich in leafy greens will help you absorb more kaempferol into your body. Still, you might also consider taking supplements or eating cannabis edibles to increase your kaempferol intake.

At ACS Laboratory, we test for 16 flavonoids, including kaempferol and quercetin. As a CLIA-licensed laboratory, we can also perform human trials on the bioavailability of these flavonoids, which is an integral part of pharmacokinetics, the study of drug movement through the body. These studies allow us to draw conclusions based on the actual science and not just anecdotal research.

The Cannabinoids Guide

This complete cannabinoid guide covers major and minor cannabinoids, how they work in the body, and highlights the top compounds brands and operators must test for today.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

The Cannabinoid Guide

The definitive resource on leading major and minor cannabinoids, how they work in the body, and what to test for.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Related Blogs

February 2, 2023

A Guide to Delta-8 vs. THCOa: Extraction, Products, Safety, Legality, Testing & More

Comparing Delta-8 THC and THCOa’s chemistry, effects, potency, and extraction methods.

Elena Schmidt

January 30, 2023

ACS Laboratory Receives 82 Emerald Badges for Exemplary Hemp and Cannabis Test Results, More Than Any Laboratory in the USA

Recently Awarded 21 Emerald Test Proficiency Badges for 2022, ACS has Reaffirmed its Position as the Most Trusted Third-party Hemp and Cannabis Testing Provider

ACS Laboratory

January 25, 2023

Comparing Exotic Cannabinoids: Delta-9 THC vs. Delta-8, Delta-10, HHC, HHCP, THC-O (THCOa), & THCP

The main difference between exotic cannabinoids and Delta-9 THC is their molecular structures, psychoactive intensity, and legality.

Elena Schmidt

December 29, 2022

A Guide to Delta-8 vs. HHC: Extraction, Products, Safety, Legality, Testing & More

Delta-8 THC is a mildly euphoric psychoactive isomer of Delta-9 THC. HHC belongs to a completely different chemical class known as hexahydrocannabinol. Learn more.

Elena Schmidt

January 19, 2023

Amanita Muscaria Part II: Active Ingredients, Effects, Nutrition & Legality

Exploring amanita muscaria’s psychoactive effects, toxic potential, edible preparation, and legality in the US and Canada.

Masha Ty

January 13, 2023

Cannabis Concentrates 101: A Guide to Terms, Usage, Potency, and Testing

Explaining the differences between cannabis concentrate types–from potency to usage to equipment and safety.

Elena Schmidt

January 5, 2023

Functional Mushrooms: Exploring Lion’s Mane, Cordyceps, and Reishi Benefits & Uses

Reviewing functional mushroom benefits, research, and top products, with a focus on reishi, lion’s mane, and cordyceps.

Masha Ty

January 3, 2023

Terpene Tuesdays: Everything You Need to Know About Farnesene Flavor, Fragrance, and Benefits

Farnesene is a cannabis terpene known as sesquiterpenes and is thought to have sedative and regulating effects on the human body and mood.

Elena Schmidt

December 9, 2022

INTERVIEW: Live Rosin Delta-8: How It's Made, Effects, Safety & Quality

Live rosin delta 8 is a cannabis concentrate made from frozen plant material and manufactured delta-8 extract. Learn more.

December 20, 2022

Terpene Tuesdays: Everything You Need to Know About Camphene Flavor, Fragrance, and Benefits

Research suggests that camphene possesses anti-microbial and antiviral properties, provides coughing relief, and may even be able to prevent heart disease.

Elena Schmidt

December 16, 2022

Amanita Muscaria (Fly Agaric): History & Toxicology of the Most Misunderstood Mushroom

Amanita mushrooms are fully legal in the United States and have a long history of use. Discovery Amanita mythology and toxicology in this ACS blog.

Masha Ty

December 14, 2022

Visit the New and Improved ACS Laboratory Website

Enhanced education, intuitive navigation, mushroom program launch, compliance updates, and more!

Elena Schmidt

December 8, 2022

Companies Producing Edibles Containing CBD and Delta-8 THC Receive New Warning Letters from the FDA

FDA recently issued new warning letters to companies that produce CBD and Delta-8 THC edibles.

December 1, 2022

THCP: Guide to THCP Effects, Products, Legality, Testing, and More

THCP has a 30X stronger binding affinity to ECS receptors than Delta-9 THC, marijuana's most abundant and powerful psychoactive agent.